Somitogenesis

638, Advances in Experimental Medicine and Biology
 Buch
Sofort lieferbar
 
This book will be of interest to scientists working in the fields of cell and developmental biology. The chapters cover topics that capture the spirit of this dynamic discipline by integrating contemporary research with the classical embryological literature.
1. Formation and Differentiation of Avian Somite Derivatives........ 1 Bodo Christ and Martin Scaal Abstract................ 1 Introduction ................. 1 Dermomyotome................ 2 Sclerotome................. 14 Outlook............. 29 2. Avian Somitogenesis: Translating Time and Space into Pa ttern.......... 42 Beate Brand-Saberi, Stefan Rudloff and Anton J. Gamel Abstract............. 42 Introduction.............. 42 Epithelialization of the segmental plate............. 43 The anterior posterior polarization of the paraxial mesoderm.............. 46 Resegmentation of the somitic derivatives.............. 49 Regionalization of somites and segmental plate............... 49 Oscillations in gene expression underlying somitogenesis........... 50 Conclusion and future considerations.............. 52 3. Genetic analysis of somite formation in laboratory fish models........... 58 Christoph Winkler and Harun Elmasri Abstract............. 58 Introduction........... 58 Genetically dissecting the clock in zebrafish: The Delta/Notch somitogenesis mutants.............. 60 Dissecting the wave front in zebrafish: FGF signalling and Tbx24............ 62 Other pathways implicated in somitogenesis............ 64 Medaka: a model complementary to zebrafish............ 64 Somite formation in the teleost medaka............. 65 Medaka somitogenesis mutants............. 66 Medaka somite mutants with PSM prepatterning defects............ 67 Medaka mutants with defective somite polarity............. 67 Conclusions and outlook............. 69 4. Old wa res and new: five decades of investigation of somitogenesis in Xenopus laevis......... 73 Duncan B. Sparrow Abstract............. 73 Introduction............ 73 Structure of the PSM............. 76 Morphological descriptions of segmentation in Xenopus............. 77 A comparison of Xenopus segmentation with that of amniote vertebrates.............. 78 What controls where the somitic furrow forms?.............. 78 Evidence for segmental Prepatterning of the PSM............. 79 Cycling genes-evidence of a "clock"?............. 81 Embryological insights into the nature of the "wavefront"............... 85 The molecular nature of the wavefront............ 86 What are the morphomechanical mechanisms required for somite separation?............. 87 Ena/VASP................ 89 Conclusion.............. 90 5. Role of Delta-Like-3 in Mammalian Somitogenesis and Vertebral Column Formation...... 95 Gavin Chapman and Sally L. Dunwoodie Abstract............. 95 Introduction.............. 95 Somitogenesis............. 95 The Notch Signalling Pathway........... 97 Notch Signalling and Somite Formation.......... 99 Dll1 and Dll3 Perform Different Functions during Somitogenesis in Mammals....... 102 Dll3 Conclusions and the Future........... 106 6. Mesp-Fa mily Genes are Required for Segmental Pa tterning and Segmental Border Formation.........113 Yumiko Saga and Yu Takahashi Abstract.......... 113 Introduction............ 113 Background of Mesp1 and Mesp2........... 114 Function of Mesp2 during Somitogenesis........... 114 Mesp2 Is also Involved in the Segment Border Formation.......... 118 Regulation of Mesp2 Expression during Somitogenesis........... 120 Functional Redundancy between Mesp1 and Mesp2........... 120 Mesp Genes in the Other Vertebrates......... 121 Perspective........... 122 7. bHLH Proteins and Their Role in Somitogenesis........... 124 Miguel Maroto, Tadahiro
We visualise developmental biology as the study ofprogressive changes that occurwithin cells, tissues and organisms themselves during their life span. A good exampleofa field ofdevelopmentalbiology in whichthis conceptis encapsulatedis thatofsomitogenesis. The somitewas identifiedas the primordialunit underlyingthe segmentedorganisationofvertebrates more than two centuries ago. The spectacular discoveries and achievements inmolecularbiologyin the last fifty years have created a gene-basedrevolution in both the sorts ofquestions as well as the approaches one can use in developmental biology today. Largely as a resultofthis, during the 20th and 21st centuries this simple structure, the somite, has been the focus ofa deluge ofpapers addressingmultipleaspectsofsomiteformation and patterning both at the cellularand molecular level. One ofthe mainreasons for suchinterest in the process ofsomitogenesis stems from the fact that it is such an exquisitelybeautiful example ofbiology working under strict temporal and spatial control in a reiterative manner that is highly conserved across the vertebrate classes. Our intention is that this book will be ofinterest to different kinds ofscientists, includingbasic researchers, pathologists, anatomists, teachersandstudentsworking in the fields ofcell and developmentalbiology. The nine chapterscoverawide array of topics that endeavour to capture the spirit of this dynamic and ever-expanding disciplineby integratingboth contemporaryresearchwith the classical embryological literaturethat concentratedon descriptionsofmorphologicalchanges inembryos and the interactionsofcells and tissues during development. Inso doingthey encompass the main aspects ofsomitogenesis across four vertebrate classes (frog, fish, mouse and chick) and the hope is that this will enable readers to acquire an appreciationof this developmentalprocess in all its facets.
Editiert von: Miguel Maroto, Neil V. Whittock
MIGUEL MAROTO is a MRC Career Development Fellow and Lecturer at the University of Dundee, UK. He received his PhD in Biochemistry and Molecular Biology from the Department of Biochemistry of the Universidad Autonoma of Madrid, Spain. His research interests include investigating the biochemical basis of different signalling mechanisms implicated in the acquisition of specific cell fates during vertebrate development. In recent years he has been involved in the analysis of the mechanism of the molecular clock in the control of the process of somitogenesis.
NEIL V. WHITTOCK gained his PhD in Human Molecular Genetics whilst working at Guys' and St Thomas' Hospitals in London, UK. His research focussed on developing diagnostic genetic tests for Duchenne muscular dystrophy before moving on to identifying genes involved in bullous skin disorders. He then continued his research as a postdoctoral fellow at the University of Dundee before arriving at the University of Exeter where he spent three years working alongside Dr Peter Turnpenny. The work at Exeter focussed on the identification of genes involved in human genetic disorders that affected the development of the spine and ribs, specifically the spondylocostal dysostoses. He now works as an Ambulance Technician in Devon, UK. and runs his own antique clock restoration business.
Autor: Miguel Maroto
ISBN-13:: 9780387096056
ISBN: 0387096051
Erscheinungsjahr: 22.12.2008
Verlag: Springer-Verlag GmbH
Gewicht: 516g
Seiten: 194
Sprache: Englisch
Sonstiges: Buch, 259x174x20 mm, 47 schwarz-weiße Abbildungen, 13 schwarz-weiße Tabellen